@page {
  size: Letter;
  margin: 0.85in 0.85in 0.95in 0.85in;
}

:root {
  --text: #152033;
  --muted: #5a6578;
  --rule: #d7deea;
  --heading: #12345a;
  --surface: #f6f8fc;
  --note-bg: #eef5ff;
  --note-border: #7aa7e0;
  --warn-bg: #fff4e5;
  --warn-border: #eea63b;
  --danger-bg: #fff1f1;
  --danger-border: #e46a6a;
}

html,
body {
  font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Helvetica, Arial, sans-serif;
  color: var(--text);
  font-size: 10.7pt;
  line-height: 1.48;
}

body {
  max-width: none;
}

h1,
h2,
h3,
h4 {
  break-after: avoid-page;
  page-break-after: avoid;
  color: var(--heading);
  margin-top: 0.95em;
  margin-bottom: 0.35em;
}

h1 {
  font-size: 22pt;
  letter-spacing: -0.01em;
}

h2 {
  font-size: 15pt;
  border-bottom: 1px solid var(--rule);
  padding-bottom: 0.16em;
}

h3 {
  font-size: 12pt;
}

p,
li {
  orphans: 3;
  widows: 3;
}

ul,
ol {
  margin-top: 0.2em;
  margin-bottom: 0.55em;
  padding-left: 1.2em;
}

table {
  border-collapse: collapse;
  width: 100%;
  margin: 0.55em 0 1em;
  break-inside: avoid;
  page-break-inside: avoid;
  font-size: 10.1pt;
}

th,
td {
  border: 1px solid var(--rule);
  padding: 0.42em 0.5em;
  vertical-align: top;
}

th {
  background: var(--surface);
  color: var(--heading);
  text-align: left;
  font-weight: 700;
}

.small-note {
  color: var(--muted);
  font-size: 9.3pt;
}

.title-page {
  min-height: 8.8in;
  display: flex;
  flex-direction: column;
}

.title-meta {
  margin-top: 1.1em;
}

.title-meta dt {
  float: left;
  width: 145px;
  font-weight: 700;
}

.title-meta dd {
  margin-left: 155px;
  margin-bottom: 0.35em;
}

.confidential {
  margin-top: 0.9em;
  border: 1px solid var(--warn-border);
  background: var(--warn-bg);
  padding: 0.6em 0.7em;
  font-weight: 700;
}

.investigational-warning {
  margin-top: 0.8em;
  border: 1px solid var(--danger-border);
  background: var(--danger-bg);
  padding: 0.7em 0.8em;
}

.callout {
  margin: 0.8em 0 1em;
  padding: 0.75em 0.85em;
  border-radius: 8px;
  break-inside: avoid;
  page-break-inside: avoid;
}

.callout.note {
  background: var(--note-bg);
  border: 1px solid var(--note-border);
}

.callout.warning {
  background: var(--warn-bg);
  border: 1px solid var(--warn-border);
}

.page-break {
  break-before: page;
  page-break-before: always;
  height: 0;
}

.figure {
  margin: 0.7em 0 1.05em;
  border: 1px solid var(--rule);
  background: #ffffff;
  padding: 0.5em;
  border-radius: 8px;
  break-inside: avoid;
  page-break-inside: avoid;
}

.figure img {
  display: block;
  width: auto;
  max-width: 100%;
  max-height: 6.5in;
  height: auto;
  margin: 0 auto;
}

.figure figcaption {
  margin-top: 0.45em;
  text-align: center;
  font-size: 9.6pt;
  color: var(--muted);
}

.no-break {
  break-inside: avoid;
  page-break-inside: avoid;
}

.toc ul,
.toc ol {
  margin-left: 1.15em;
}

hr {
  border: none;
  border-top: 1px solid var(--rule);
  margin: 0.8em 0;
}